In Django, __icontains and __in are field lookups to the QuerySet methods. __icontains is a case-insensitive containment test, and __in means that the field is in a given iterable. So I would like to do the following lookup:

keywords = ['How', 'to', 'setup', 'PrismJS', 'and', 'Autoloader', 'plugin', 'with', 'Nuxt', '3?']
#Possible keywords of title
Writings.objects.filter(title__icontains__in=arr)

Unfortunately, we can not combine field lookups in Django.

To implement our desire, we can use Q() objects (see Complex lookups with Q objects), and combine them with | operator by looping.

from django.db.models import Q

def title_matching(merchants):
    """
    Return a queryset for writings whose titles contain case-insensitive
    matches for any of the `keywords`.
    """
    q = Q()
    for key in keywords:
        q |= Q(title__icontains = key)
    return Writings.objects.filter(q)

Similarly, we can use the same way to combine __iexact with __in.